High blood pressure makes the heart work harder to pump blood throughout the body and causes damage to the blood vessels. If high blood pressure is not treated, it can lead to stroke, heart attack, heart failure, kidney failure, and vision problems. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Go AS, Bauman MA, Coleman King SM et al. An effective approach to high blood pressure control: a science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention. Hypertension. Concomitant use of telmisartan and aliskiren in patients with diabetes mellitus. a 550 See Specific Drugs under Interactions. Not metabolized by CYP isoenzymes; has no effect on CYP isoenzymes except for some inhibition of CYP2C19 in vitro.
Keep out of the reach of children. Micardis is available as tablets for oral administration, containing 20 mg, 40 mg or 80 mg of telmisartan. The tablets contain the following inactive ingredients: sodium hydroxide, meglumine, povidone, sorbitol, and magnesium stearate. Micardis tablets are hygroscopic and require protection from moisture. Micardis HCT may cause drowsiness, dizziness, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Micardis HCT with caution. Clinical study of the month. Nephroprotective role of angiotensin II receptor antagonists in type 2 diabetes: results of IDNT and RENAAL trials.
Carefully monitor BP during initial titration or subsequent upward adjustment in dosage. Walser M. Angiotensin-receptor blockers, type 2 diabetes, and renoprotection. N Engl J Med. Anon. Drugs for hypertension. Med Lett Drugs Ther. Neutel JM, Smith DHG. Dose response and antihypertensive efficacy of the AT1 receptor antagonist telmisartan in patients with mild to moderate hypertension. Adv Ther.
ACCF, AHA, and the Heart Failure Society of America HFSA recommend that patients with chronic symptomatic heart failure and reduced LVEF NYHA class II or III who are able to tolerate an ACE inhibitor or angiotensin II receptor antagonist be switched to therapy containing an ARNI to further reduce morbidity and mortality. Continue to take Micardis HCT even if you feel well. Do not miss any doses. Pasternak B, Svanström H, Callréus T et al. Use of angiotensin receptor blockers and the risk of cancer. Circulation. Increases in BUN and S cr possible in patients with unilateral or bilateral renal artery stenosis. Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium. Who should not take Micardis? Although telmisartan may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause serious kidney problems or make them worse. Your doctor will check your kidney function while you are taking telmisartan. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of telmisartan in the elderly. Micardis is a medicine that contains the active substance telmisartan. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. American Stroke Association. Stroke. Boehringer Ingelheim. Micardis HCT telmisartan and hydrochlorothiazide tablets prescribing information. It is driving me crazy! The information contained in the Truven Health Micromedex products as delivered by Drugs. Tell your doctor or dentist that you take Micardis HCT before you receive any medical or dental care, emergency care, or surgery. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Cleve Clin J Med. plendil
Unger T. Significance of angiotensin type 1 receptor blockade: why are angiotensin II receptor blockers different? This medication is used to treat high blood pressure hypertension. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Telmisartan belongs to a class of drugs called angiotensin receptor blockers ARBs. It works by relaxing blood vessels so blood can flow more easily. Volpe M, Morganti A. 2010 Position Paper of the Italian Society of Hypertension SIIA: Angiotensin Receptor Blockers and Risk of Cancer. High Blood Press Cardiovasc Prev. Lab tests, including kidney function, blood pressure, and blood electrolytes, may be performed while you use Micardis HCT. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Martineau P, Goulet J. New competition in the realm of renin-angiotensin axis inhibition; the angiotensin II receptor antagonists in congestive heart failure. Ann Pharmacother. This product may affect your levels. Before using potassium or salt substitutes that contain potassium, consult your doctor or pharmacist. In the treatment of essential hypertension, Micardis was more effective than placebo at reducing diastolic blood pressure and had similar effects to the other medicines for hypertension. Food and Drug Administration FDA does not regulate in the same way it regulates medicines. A dietary supplement can be sold with limited or no research on how well it works or on its safety. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Read the Patient Information Leaflet if available from your pharmacist before you start taking telmisartan and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Micardis for 4 years now. evik.info cabergoline
You may take telmisartan with or without food. Initially, 40 mg once daily in adults without intravascular volume depletion. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. What should I tell my doctor before taking Micardis tablets? Does Micardis oral have side effects? Plasma concentrations of telmisartan are generally 2 to 3 times higher in females than in males. In clinical trials, however, no significant increases in blood pressure response or in the incidence of orthostatic hypotension were found in women. No dosage adjustment is necessary. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Do not share this medication with others. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Perk J, De Backer G, Gohlke H et al. European Guidelines on cardiovascular disease prevention in clinical practice version 2012. The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice constituted by representatives of nine societies and by invited experts. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.
Hg may still be considered. In studies of ACE inhibitors in patients with unilateral or bilateral renal artery stenosis, increases in serum creatinine or blood urea nitrogen were observed. There has been no long term use of Micardis in patients with unilateral or bilateral renal artery stenosis, but anticipate an effect similar to that seen with ACE inhibitors. Ismail I, Singh R, Sirisinghe RG. Rehydration with sodium-enriched coconut water after exercise-induced dehydration. If you have any questions about Micardis HCT, please talk with your doctor, pharmacist, or other health care provider. Sica DA. Angiotensin receptor blockers and the risk of malignancy: a note of caution. Drug Saf. buy kemadrin online ireland
American Heart Association Task Force on Practice Guidelines. Circulation. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. The mean duration of follow up was about 4 years and 6 months. It is not known whether hydrochlorothiazide and telmisartan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using this medication. This list is not complete. Other drugs may interact with telmisartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Cooper WO, Hernandez-Diaz S, Arbogast PG et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. N Engl J Med. Micardis HCT contains a sulfonamide called hydrochlorothiazide, which can cause certain eye problems myopia, angle-closure glaucoma. Your risk may be increased if you are allergic to sulfonamide medicines eg, sulfamethoxazole or to penicillin antibiotics eg, amoxicillin. Untreated angle-closure glaucoma can lead to permanent vision loss. If these eye problems occur, symptoms usually occur within hours to weeks of starting Micardis HCT. Contact your doctor immediately if you experience symptoms, such as vision changes eg, decreased vision clearness or eye pain. In rare cases, telmisartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and telmisartan. You may need to stop using the medicine for a short time. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. The mean duration of follow up was 4 years and 8 months. The population studied was 57% male, 62% Caucasian, 21% Asian, and 60% were 65 years of age or older. Baseline therapy included acetylsalicylic acid 75% lipid lowering agents 58% beta-blockers 58% calcium channel blockers 41% nitrates 34% and diuretics 33%. All medicines may cause side effects, but many people have no, or minor, side effects. Telmisartan: No initial dosage adjustments necessary. In placebo-controlled trials involving 1041 patients treated with various doses of Micardis 20 to 160 mg monotherapy for up to 12 weeks, the overall incidence of adverse events was similar to that in patients treated with placebo. Dizziness, lightheadedness, or fainting may occur with this medicine, especially when you get up suddenly from a lying or sitting position. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. Micardis has been evaluated for safety in more than 3700 patients, including 1900 treated for over 6 months and more than 1300 for over one year. Adverse experiences have generally been mild and transient in nature and have infrequently required discontinuation of therapy. how to store cut telmisartan
National Heart, Lung, and Blood Institute National High Blood Pressure Education Program. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC 7. Bethesda, MD: National Institutes of Health; 2004 Aug. NIH publication No. 04-5230. Because clinical studies are conducted under widely varying conditions, adverse reactions rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice. Micardis, including the appropriate precautions to be followed by healthcare professionals and patients. Salt-Depleted Patients under Dosage and Administration. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.
Blocks the physiologic actions of angiotensin II, including vasoconstrictor and aldosterone-secreting effects. Plasma telmisartan concentrations may be increased in patients with obstructive biliary disease or hepatic impairment. 1 2 See Special Populations under Absorption, in Pharmacokinetics. Elliott HL. The efficacy and safety of telmisartan compared to atenolol and placebo in patients with hypertension. Am J Hypertens. 1998; 11Part 2: 124A. High potassium in the blood hyperkalemia. Your doctor may check your potassium levels as needed. Angiotensin II receptor antagonists may be used as an alternative for those patients in whom an ACE inhibitor or ARNI is inappropriate. Izzo JL, Levy D, Black HR. Importance of systolic blood pressure in older Americans. Hypertension. Store tablets in their original package at room temperature away, from moisture and heat. What happens if I miss a dose? Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Special Senses: abnormal vision, conjunctivitis, tinnitus, earache. Tiredness and may also occur. If any of these effects persist or worsen, tell your doctor or promptly. Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is widely used in the treatment of hypertension. ACE inhibitors also inhibit the degradation of bradykinin, a reaction also catalyzed by ACE. Because telmisartan does not inhibit ACE kininase II it does not affect the response to bradykinin. Whether this difference has clinical relevance is not yet known. Telmisartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. Therapeutic Research Faculty 2009. Distributed into milk in rats; not known whether distributed into human milk. average cost of terazosin without insurance
There were no changes in the heart rate of patients treated with telmisartan in controlled trials. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Micardis tablets for a condition for which it was not prescribed. Do not give Micardis tablets to other people, even if they have the same condition you have. It may harm them. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. AHA guidelines for the evaluation and management of chronic heart failure in the adult. Micardis must not be used in women who are more than three months pregnant. Its use during the first three months of pregnancy is not recommended. Micardis must not be used in people who have severe liver problems or bile problems. In patients with type 2 diabetes or in patients with moderate or severe kidney impairment, Micardis must also not be used in combination with aliskiren-containing medicines also used to treat essential hypertension. For the full list of restrictions, see the package leaflet. Why has Micardis been approved? Other than for vitamins and minerals, the long-term effects of most dietary supplements are not known. Alleyne T, Roache S, Thomas C, Shirley A. The control of hypertension by use of coconut water and mauby: two tropical food drinks. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Talk to your doctor or about lifestyle changes that might benefit you. promethazine
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Hypotension may be more common in patients receiving Micardis to prevent cardiovascular problems. For the full list of all side effects reported with Micardis, see the package leaflet. Food and Drug Administration. FDA drug safety communication: No increase in risk of cancer with certain blood pressure drugs-angiotensin receptor blockers ARBs. Rockville, MD; 2011 Jun 2. Available from FDA website. Symptoms may include fainting; fast, slow, or irregular heartbeat; severe or unusual dizziness; symptoms of blood electrolyte problems eg, confusion; irregular heartbeat; mental or mood changes; muscle pain, weakness, or cramping; seizures; sluggishness; symptoms of dehydration eg, drowsiness; dry eyes; fast heartbeat; nausea; restlessness; unusual thirst, tiredness, or weakness; vomiting.
Parving HH, Lehnert H, Brochner-Mortensen J et al and the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med. Report any light-headedness or fainting to your doctor immediately. Your risk of light-headedness or fainting may be increased if you experience diarrhea, vomiting, excessive sweating; do not drink enough fluids; or are on a low-salt diet. Kidney problems, which may get worse if you already have kidney disease. You may have changes in your kidney test results, and you may need a lower dose of Micardis tablets.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. The medicine can only be obtained with a prescription. How is Micardis used? Do not keep outdated medicine or medicine no longer needed. It is not known whether telmisartan is excreted in human milk, but telmisartan was shown to be present in the milk of lactating rats. Because of the potential for adverse effects on the nursing infant, decide whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Manufacturers state fixed-combination preparation should not be used for initial antihypertensive therapy. FDA pregnancy category D. Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Hydrochlorothiazide and telmisartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control. Frohlich ED. Recognition of systolic hypertension for hypertension. Hypertension. Remuzzi G. Slowing the progression of diabetic nephropathy. N Engl J Med.